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Abstract Title:

Effect of vitamin C administration on neutrophil apoptosis in septic patients after abdominal surgery.

Abstract Source:

J Surg Res. 2009 May 15 ;153(2):224-30. Epub 2008 May 21. PMID: 18952228

Abstract Author(s):

Ignacio Ferrón-Celma, Alfonso Mansilla, Laila Hassan, Ana Garcia-Navarro, Ana-Maria Comino, Pablo Bueno, Jose-Antonio Ferrón

Article Affiliation:

Ignacio Ferrón-Celma

Abstract:

OBJECTIVE: To investigate the effect of parenteral administration of vitamin C on neutrophil apoptosis by determining Fas receptor expression and caspase-3, poly (ADP-ribose) polymerase (PARP), and Bcl-2 levels in neutrophils from septic abdominal surgery patients.

STUDY DESIGN: Twenty septic abdominal surgery patients were studied in a prospective, randomized, double-blinded clinical trial. A group of healthy volunteers (n = 10) constituted a reference group for baseline parameter values. The patients were randomly assigned to a vitamin C-treated (n = 10) or placebo-treated (n = 10) group. For a 6-d period from 12 h post-surgery, the vitamin C group received 450 mg/d of the vitamin in 3 doses and the placebo group an identical administration of 5% dextrose. Early-morning peripheral blood samples were obtained daily from 24 h after vitamin C administration until d 6 post-surgery (T1d-T6d).

RESULTS: Vitamin C group showed a nonsignificant reduction in Fas (CD95) expression on CD15-positive peripheral blood neutrophils, significantly decreased caspase-3, and PARP levels (caspase-3: T4d: P<0.05, T5d: P<0.05, T6d P<0.01; and PARP: T3d: P<0.05, T4d: P<0.05, T6d: P<0.05), and significantly increased Bcl-2 levels (T3d: P = 0.001) versus placebo group.

CONCLUSIONS: Postoperative vitamin C treatment of septic abdominal surgery patients exerts an antiapoptotic effect on peripheral blood neutrophils, reducing caspase-3 and PARP levels, and increasing Bcl-2 levels. However, these antiapoptotic effects are not maintained at all time points.

Study Type : Human Study

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Sayer Ji
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