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Article Publish Status: FREE
Abstract Title:

The effect of sinomenine eye drops on experimental dry eye in mice.

Abstract Source:

Cutan Ocul Toxicol. 2020 Dec ;39(4):389-395. Epub 2020 Nov 6. PMID: 33103493

Abstract Author(s):

Hui Li, Feng Wei, Shiwei Li, Liang Yan, Peirong Lu

Article Affiliation:

Hui Li

Abstract:

OBJECTIVE: To investigate the effect of topical sinomenine (SIN) on ocular surface damage in experimental dry eye in mice.

MATERIAL AND METHODS: Experimental dry eye was created using scopolamine hydrobromide in female C57BL/6 mice. Eye drops consisting of 0.05%, or 0.1% SIN or phosphate-buffered saline (PBS) were applied to the experimental dry eye in mice. Tear product and corneal staining scores were measured at 7 and 14 days after treatment. Interleukin (IL)-1β and tumour necrosis factor (TNF)-α levels in the SIN groups at 14 days after treatment were compared with those of other groups.

RESULTS: Mice treated with 0.05% or 0.1% SIN showed a significant improvement in tear product and corneal irregularity compared to the control and PBS-treated groups. A significant decrease in the levels of IL-1βand TNF-α was observed in the 0.05% and 0.01% SIN-treated groups.

CONCLUSIONS: Topical SIN eye drop application can effectively improve clinical signs and decrease inflammation in the ocular surface, and alleviate ocular surface damage in dry eye.

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