Abstract Title:

Cytotoxic activity and G1 cell cycle arrest of a Dienynone from Echinacea pallida.

Abstract Source:

Planta Med. 2010 Mar;76(5):444-6. Epub 2009 Oct 20. PMID: 19844866

Abstract Author(s):

Andrea Chicca, Barbara Adinolfi, Federica Pellati, Giulia Orlandini, Stefania Benvenuti, Paola Nieri

Article Affiliation:

Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa, Italy. andrea.chicca@ittumori.it


In the present study, a further investigation of the cytotoxic activity of an acetylenic constituent of Echinacea pallida roots, namely, pentadeca-(8 Z,13 Z)-dien-11-yn-2-one, was performed, revealing a concentration-dependent cytotoxicity on several human cancer cell lines, including leukemia (Jurkat and HL-60), breast carcinoma (MCF-7), and melanoma (MeWo) cells. As part of its mechanism of action, the ability of this constituent to arrest the cell cycle in the G1 phase was demonstrated on HL-60 cells. Furthermore, a stability test of the target compound over 72 h was carried out, indicating that the cytotoxic activity can be attributed mainly to the genuine, not oxidized, molecule.

Study Type : In Vitro Study

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