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Article Publish Status: FREE
Abstract Title:

Dissolving microneedles for transdermal delivery of huperzine A for the treatment of Alzheimer's disease.

Abstract Source:

Drug Deliv. 2020 Dec ;27(1):1147-1155. PMID: 32729341

Abstract Author(s):

Qinying Yan, Weiwei Wang, Jiaqi Weng, Zhenghan Zhang, Lina Yin, Qingliang Yang, Fangyuan Guo, Xingang Wang, Fan Chen, Gensheng Yang

Article Affiliation:

Qinying Yan

Abstract:

Increasingly attention has been paid to the transdermal drug delivery systems with microneedles owing to their excellent compliance, high efficiency, and controllable drug release, therefore, become promising alternative with tremendous advantages for delivering specific drugs such as huperzine A (Hup A) for treatment of Alzheimer's disease (AD) yet with low oral bioavailability. The purpose of the present study is to design, prepare, and evaluate a dissolving microneedle patch (DMNP) as a transdermal delivery system for the Hup A, investigating itsdrug release profiles andpharmacokinetics as well as pharmacodynamics treating of AD. Skin penetration experiments and intradermal dissolution tests showed that the blank DMNP could successfully penetrate the skin with an adequate depth and could be quickly dissolved within 5 min.transdermal release tests exhibited that more than 80% of the Hup A was accumulatively permeated from DMNP through the skin within three days, indicating a sustained release profile.pharmacokinetic analysis demonstrated that the DMNP group resulted in longer(twofold), longer(fivefold), lower(3:4), and larger AUC(twofold), compared with the oral group at the same dose of Hup A. Pharmacodynamic research showed a significant improvement in cognitive function in AD rats treated with DMNP-Hup A and Oral-Hup A, as compared to the model group without treatment. Those results demonstrated that this predesigned DMNP is a promising alternative to deliver Hup A transdermally for the treatment of AD.

Study Type : In Vitro Study

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