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Abstract Title:

Diosmetin inhibits the expression of alpha-hemolysin in Staphylococcus aureus.

Abstract Source:

Antonie Van Leeuwenhoek. 2015 Aug ;108(2):383-9. Epub 2015 May 29. PMID: 26021482

Abstract Author(s):

Shui Liu, Xuan Zhou, Wenhua Li, Hong Zhang, Bing Zhang, Gen Li, Bowen Liu, Xuming Deng, Liping Peng

Article Affiliation:

Shui Liu

Abstract:

Staphylococcus aureus is a significant human pathogen that causes a wide range of diseases. Alpha-hemolysin (Hla), a pore-forming cytotoxin that is produced by most S. aureus strains, can cause tissue injury and plays a critical role in the virulence of this pathogen. In the present study, we discovered that diosmetin, a natural flavonoid that occurs primarily in citrus fruits and exhibits little anti-S. aureus activity, could diminish the production of Hla in culture supernatants in a concentration-dependent manner. The analysis of cytotoxicity in the co-culture system of S. aureus and A549 epithelial cells showed that such inhibition confers significant protection against S. aureus-mediated injury. Our results suggested that diosmetin has the potential to be a new anti-virulence drug for S. aureus infection, particularly for the targeting of Hla.

Study Type : In Vitro Study

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