Abstract Title:

Dietary Fermentable Fiber Reduces Intestinal Barrier Defects and Inflammation in Colitic Mice.

Abstract Source:

J Nutr. 2016 Sep 7. Epub 2016 Sep 7. PMID: 27605405

Abstract Author(s):

Tran Van Hung, Takuya Suzuki

Article Affiliation:

Tran Van Hung


BACKGROUND: Dietary fiber (DF) and its fermentation metabolites play an important role in establishing and maintaining intestinal health.

OBJECTIVE: This study investigated the effects of fermentable DF, guar gum (GG), and partially hydrolyzed GG (PHGG) on the epithelial tight junction (TJ) barrier and inflammation in a murine model of dextran sodium sulfate (DSS)-induced colitis.

METHODS: In Expt. 1, male, 7-wk-old BALB/c mice weighing∼21 g were fed diets with 0%, 5%, and 10% GG for 12 d and administered distilled water with 2% DSS for 7 d beginning 5 d after the start of feeding. In Expt. 2, mice were provided diets with or without 10% PHGG and GG for 13 d and administered distilled water with 2% DSS for 8 d from 5 d after thestart of feeding. In Expt. 3, mice were provided diets with or without 10% PHGG and GG for 14 d without DSS administration. Colitis score, colon TJ proteins, and fecal SCFA concentrations were analyzed.

RESULTS: In Expts. 1 and 2, the clinical score in the DSS group was∼100% greater than that in the DSS+10% GG and PHGG groups on days 12 and 13 (P<0.01). The DSS+10% GG and PHGG groups showed∼110%, 60%, 120%, and 110% greater (P<0.05) expression of occludin and claudin 3, 4, and 7, respectively, in the colon than did the DSS group. The DSS+10% GG and PHGG groups had greater total fecal SCFA concentrations (25.1 and 12.0 mmol/L) than did the DSS group (3.3 mmol/L) on day 9 (P<0.01). TJ protein expression did not differ between groups in Expt. 3.

CONCLUSION: These findings suggest that microbial metabolites of PHGG and GG, and possibly SCFAs, reduce intestinal barrier defects and inflammation in colitic mice.

Study Type : Animal Study

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