D-limonene exerts its cytotoxic effect on BGC-823 gastric cancer cells by inducing apoptosis. - GreenMedInfo Summary

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Abstract Title:

[D-limonene induces apoptosis of gastric cancer cells].

Abstract Source:

Zhonghua Zhong Liu Za Zhi. 2003 Jul ;25(4):325-7. PMID: 12921557

Abstract Author(s):

Xiao-guang Lu, Bing-an Feng, Li-bin Zhan, Zhi-hong Yu

Article Affiliation:

Xiao-guang Lu

Abstract:

OBJECTIVE: To investigate the apoptosis effect induced by D-limonene on BGC-823 gastric cancer cells.

METHODS: The expression of p53, bc1-2 in BGC-823 cells and qualitative, quantitative index of cell apoptosis were detected with MTT, electron microscopy, flow cytometry and immunohistochemical method.

RESULTS: D-limonene could induce the formation of apoptotic bodies in a dose- and time-dependent manner. The expression of bcl-2 protein decreased and p53 protein increased in BGC-823 cells treated with D-limonene, compared with the control cells.

CONCLUSION: D-limonene exerts its cytotoxic effect on BGC-823 gastric cancer cells by inducing apoptosis.

Article Published Date : Jun 30, 2003

Study Type : In Vitro Study

Additional Links

Substances : D-Limonene : CK(21) : AC(9)

Diseases : Gastric Cancer : CK(836) : AC(341)

Pharmacological Actions : Apoptotic : CK(5217) : AC(3846), Bcl-2 protein down-regulation : CK(419) : AC(295), Tumor Suppressor Protein p53 Upregulation : CK(480) : AC(343)

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D-limonene exerts its cytotoxic effect on BGC-823 gastric cancer cells by inducing apoptosis. - GreenMedInfo Summary

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