Article Publish Status: FREE
Abstract Title:

Curcumin for the Treatment of Glioblastoma.

Abstract Source:

Anticancer Res. 2015 Dec ;35(12):6373-8. PMID: 26637846

Abstract Author(s):

Laura A Sordillo, Peter P Sordillo, Lawrence Helson

Article Affiliation:

Laura A Sordillo

Abstract:

Glioblastoma multiforme is a highly aggressive primary cancer of the brain associated with a poor prognosis. Modest increases in survival can sometimes be achieved with the use of temozolomide and radiation therapy after surgery, but second-line therapy after recurrence has a limited efficacy. Curcumin has demonstrated promising results against this form of cancer in experimental models. The reported activity of curcumin against cancer stem cells, a major cause of glioblastoma resistance to therapy, and its ability to augment the apoptotic effects of ceramides, suggest it would have a synergistic effect with cytotoxic chemotherapy agents currently used in second-line therapy, such as lomustine.

Study Type : Review

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Sayer Ji
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