Abstract Title:

Curcumin prevents the development of dextran sulfate Sodium (DSS)-induced experimental colitis.

Abstract Source:

Dig Dis Sci. 2007 Nov;52(11):2993-8. Epub 2007 Apr 11. PMID: 17429738

Abstract Author(s):

Yasuyuki Deguchi, Akira Andoh, Osamu Inatomi, Yuhki Yagi, Shigeki Bamba, Yoshio Araki, Kazunori Hata, Tomoyuki Tsujikawa, Yoshihide Fujiyama

Article Affiliation:

Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, 520-2192, Japan.

Abstract:

Curcumin is a phenolic natural product isolated from the rhizome of Curcuma longa (turmeric). We evaluated the effects of curcumin on the development of dextran sulfate sodium (DSS)-induced experimental colitis. BALB/c mice were fed a chow containing either 3.5% (wt/wt) DSS or 3.5% DSS + 2.0% (wt/wt) curcumin. The body weight loss was more apparent in DSS-treated mice than in DSS + curcumin-treated mice. The disease activity index, histological colitis score, and MPO activity were all significantly higher in DSS-treated mice than in DSS plus curcumin-treated mice. Microscopically, mucosal edema, cellular infiltration, and epithelial disruption were much more severe in DSS-treated mice than in DSS + curcumin-treated mice. In DSS + curcumin-treated mice, NF-kappaB activation was blocked in the mucosa. In conclusion, the development of DSS-induced colitis was significantly attenuated by curcumin. Being a nontoxic natural dietary product, curcumin could be useful in treatment of IBD patients.

Study Type : Animal Study

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