Abstract Title:

Effects of curcumin on N-bis(2-hydroxypropyl) nitrosamine (DHPN)-induced lung and liver tumorigenesis in BALB/c mice in vivo.

Abstract Source:

In Vivo. 2008 Nov-Dec;22(6):781-5. PMID: 19181006

Abstract Author(s):

An-Cheng Huang, Shuw-Yuan Lin, Chin-Cheng Su, Song-Shei Lin, Chin-Chin Ho, Te-Chun Hsia, Tsan-Hung Chiu, Chun-Shu Yu, Siu-Wan Ip, Tsung-Ping Lin, Jing-Gung Chung

Article Affiliation:

Department of Pharmacy, Yuan-Lin Kuo Hospital, Yuanlin Town, Changhua County 510, Taiwan.

Abstract:

Curcumin (diferuloylmethane), a phenolic compound from the plant Curcuma longa (Linn.) has been shown to exhibit antitumor activity and apoptosis in many human cancer cell lines including that of lung and liver cancer. In this study, curcumin was evaluated in BALB/c mice for its ability to inhibit pulmonary and liver adenoma formation and growth after they were orally treated with N-bis(2-hydroxypropyl)nitrosamine (DHPN). Animals were treated with DHPN in water for approximately 14 days before multiple doses of curcumin were given intraperitoneally. It was found that 200 microM curcumin reduced lung and liver tumor multiplicity by 37% (p<0.05) and 30% (p<0.05) respectively. The results indicated that curcumin significantly inhibited pulmonary and liver adenoma formation and growth in BALB/c mice. The precise mechanism by which curcumin inhibits lung and liver tumorigenesis remains to be elucidated. Thus, curcumin appears to be a promising new chemotherapeutic and preventive agent for lung and liver cancer induced by DHPN.

Study Type : Animal Study

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