Abstract Title:

Inhibitory effect on curcumin on mammalian phospholipase D activity.

Abstract Source:

FEBS Lett. 1997 Nov 10;417(2):196-8. PMID: 9395294

Abstract Author(s):

H Yamamoto, K Hanada, K Kawasaki, M Nishijima

Article Affiliation:

Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, Toyama, Tokyo, Japan.

Abstract:

Curcumin, the major yellow pigment of turmeric (Curcuma longa), has strong anti-carcinogenic and anti-inflammatory activities. We examined the effects of curcumin on enzyme activities of the following phospholipases in a cell-free system: G protein-mediated phospholipase D (PLD), phosphatidylinositol-specific phospholipase C, and phospholipase A2 from mouse macrophage-like cell line J774.1 cells, sphingomyelinase from bovine brain, and phosphatidylcholine-phospholipase C from Bacillus cereus. Curcumin inhibited several types of phospholipases, most effectively PLD among those tested. It also inhibited 12-O-tetradecanoylphorbol-13-acetate-induced PLD activation in intact J774.1 cells in a dose-dependent manner. These results suggest that the anti-inflammatory and anti-carcinogenic action of curcumin is partly due to the inhibition of PLD.

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