Abstract Title:

[Effect of three different curcumin pigmens on the prdiferation of vascular smooth muscle cells by ox-LDL and the expression of LDL-R].

Abstract Source:

Zhongguo Zhong Yao Za Zhi. 2006 Mar;31(6):500-3. PMID: 16722385

Abstract Author(s):

Yan Liu, Xing-Qiu Hong

Article Affiliation:

Zhejiang Traditional Medical College, Hangzhou 310009, China.

Abstract:

OBJECTIVE: To investigate the anti-proliferation of three different structural curcumin pigmen monomers on the bovine VSMC stimulated by ox-LDL and the effect on the expression of LDL-R.

METHOD: MTT and FCM were used to observe the anti-proliferation of three different on the bovine VSMC stimulated by ox-LDL and the effect on the expression of LDL-R.

RESULT: ox-LDL(2.5,5, 10 mg x L(-1)) had obvious proliferative effect on VSMC, P<0.05, curcumin (16.5,33,66 micromol x L(-1)), demethoxycurcumin (33,66 micromol x L(-1)) and bisdemethoxycurcumin (66 micromol x L(-1)) had obvious inhibition effect on the proliferation of VSMC stimulated by 10 mg x L(-1) ox-LDL (P<0.05, curcumin>demethoxycurcumin>bisdemethoxycurcumin) . Three curcumin (16.5,33,66 micromol x L(-1)) could obviously activate the expression of LDLR of VSMC.

CONCLUSION: The three different structural curcumin pigmen monomers can not only inhibit the proliferation of bovine VSMC obviously stimulated by ox-LDL, but also promote the expression of LDL-R on bovine VSMC, that may be the mechanism of delaying the development of arteriosclerosis.

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