Abstract Title:

Colorectal cancer: chemopreventive role of curcumin and resveratrol.

Abstract Source:

Nutr Cancer. 2010 Oct;62(7):958-67. PMID: 20924971

Abstract Author(s):

Vaishali B Patel, Sabeena Misra, Bhaumik B Patel, Adhip P N Majumdar

Article Affiliation:

Veterans Affairs Medical Center, Wayne State University, Detroit, Michigan 48201, USA.

Abstract:

Colorectal cancer (CRC) is a second leading cause of cancer deaths in the Western world. Currently there is no effective treatment except resection at a very early stage with or without chemotherapy. Of various epithelial cancers, CRC in particular has a potential for prevention, since most cancers follow the adenoma-carcinoma sequence, and the interval between detection of an adenoma and its progression to carcinoma is usually about a decade. However no effective chemopreventive agent except COX-2 inhibitors, limited in their scope due to cardiovascular side effects, have shown promise in reducing adenoma recurrence. To this end, natural agents that can target important carcinogenic pathways without demonstrating discernible adverse effects would serve as ideal chemoprevention agents. In this review, we discuss merits of two such naturally occurring dietary agents-curcumin and resveratrol-for chemoprevention of CRC.

Study Type : Review

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