n/a
Abstract Title:

Cucumol B, a new triterpene benzoate fromseeds with cytotoxic effect toward ovarian and human breast adenocarcinoma.

Abstract Source:

J Asian Nat Prod Res. 2019 Nov ;21(11):1112-1118. Epub 2018 Jun 27. PMID: 29947257

Abstract Author(s):

Sabrin Ragab Mohamed Ibrahim, Amgad Ibrahim Mansour Khedr, Gamal Abdallah Mohamed, Mohamed Fathalla Zayed, Amal Abd-Elmoneim Soliman El-Kholy, Rwaida Adel Al Haidari

Article Affiliation:

Sabrin Ragab Mohamed Ibrahim

Abstract:

Phytochemical investigation of the methanolic extract ofL. (Cucurbitaceae) seeds furnished a new triterpene benzoate derivative: cucumol B () and four known flavonoids: quercetin-3---D-glucopyranosyl-(1→6)--L-rhamnopyranoside (), quercetin-3---D-glucopyranoside (), quercetin (), and luteolin (). Their structures were identified by UV, IR, 1D (C andH), 2D (HSQC,H-H COSY, HMBC, and NOESY) NMR, and HRESIMS spectral as well as comparing with literature data. Compoundhas been assessed for thecytotoxic effect against SKOV-3, MCF-7, and HCT-116 cell lines. It had selective and potent effect toward SKOV-3 and MCF-7 cell lines with ICs 2.05 and 0.41 μM, respectively, in comparison to doxorubicin (ICs 0.32 and 0.05 μM). However, it showed moderate activity toward HCT-116 cell line with IC8.27 μM.

Study Type : In Vitro Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.