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Abstract Title:

Aqueous Coriandrum sativum L. extract promotes neuroprotection against motor changes and oxidative damage in rat progeny after maternal exposure to methylmercury.

Abstract Source:

Food Chem Toxicol. 2019 Nov ;133:110755. Epub 2019 Aug 10. PMID: 31408720

Abstract Author(s):

Keuri Eleutério Rodrigues, Fábio Rodrigues de Oliveira, Benilson Ramos Cassunde Barbosa, Ricardo S Oliveira Paraense, Cahy Manoel Bannwart, Bruno Gonçalves Pinheiro, Anderson de Santana Botelho, Nilton Akio Muto, Cristine Bastos do Amarante, Moises Hamoy, Barbarella de Matos Macchi, Cristiane do Socorro Ferraz Maia, Alejandro Ferraz do Prado, José Luiz Martins do Nascimento

Article Affiliation:

Keuri Eleutério Rodrigues

Abstract:

This study aimed to investigate the effects of Coriandrum sativum aqueous extract (CSAE) on the rat progeny of mothers exposed to methylmercury (MeHg). The presence of bioactive compounds and CSAE's antioxidant capacity been evaluated, and the offspring were assessed for their total mercury levels, motor behavioral parameters and oxidative stress in the cerebellum. The analysis of the bioactive compounds revealed significant amounts of polyphenols, flavonoids, and anthocyanins, as well as a variety of minerals. A DPPH test showed the CSAE had important antioxidant activity. The MeHg + CSAE group performed significantly better spontaneous locomotor activity, palmar grip strength, balance, and motor coordination in behavioral tests compared the MeHg group, as well as in the parameters of oxidative stress, with similar results to those of the control group. The MeHg + CSAE group also had significantly reduced mercury levels in comparison to the MeHg group. Based on the behavioral tests, which detected large locomotor, balance, and coordination improvements, as well as a reduction in oxidative stress, we conclude that CSAE had positive functional results in the offspringof rats exposed to MeHg.

Study Type : Animal Study

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