Constituents of L. fulvotomentosa and L. macranthoide are effective in decreasing carbon tetrachloride and D-Galactosamine-induced liver injuries. - GreenMedInfo Summary
[Hepatoprotective effect of several constituents of Lonicera fulvotomentosa hsu et S. C. cheng, and L. macranthoide Hand.-Mazz. on CC1(4) and D-galactosamine induced liver injuries in mice and rats].
Zhongguo Zhong Yao Za Zhi. 1999 Jun ;24(6):363-4, 384. PMID: 12212032
J Shi
OBJECTIVE: To study the hepatoprotective effect of several constituents of Lonicera fulvotomentosa and L. macranthoide on CC1(4) and D-Galactosamine induced liver injury in mice and rats.
METHOD: Mice and rats were given s.c. several constituents of L. fulvotomentosa and L. macranthoide, sGPT, hepatic triglycerides(TG) and malondialdehyde (MDA) were determined.
RESULTS: All the compounds reduced the rise of sGPT and TG induced by CC1(4) and D-Galactosamine. Hepatic MDA formation caused by CC1(4) was also significantly decreased.
CONCLUSION: Several constituents of L. fulvotomentosa and L. macranthoide are effective in decreasing CC1(4) and D-Galactosamine-induced liver injuries, and this effect appears to be due to the decrease of lipid peroxidation of CC1(4).
