Article Publish Status: FREE
Abstract Title:

STAT3 and NF-κB are common targets for kaempferol-mediated attenuation of COX-2 expression in IL-6-induced macrophages and carrageenan-induced mouse paw edema.

Abstract Source:

Biochem Biophys Rep. 2017 Dec ;12:54-61. Epub 2017 Aug 26. PMID: 28955792

Abstract Author(s):

Anandita Basu, Anindhya Sundar Das, Manoj Sharma, Manash Pratim Pathak, Pronobesh Chattopadhyay, Kaushik Biswas, Rupak Mukhopadhyay

Article Affiliation:

Anandita Basu


Cycloxygenase-2 (COX-2) is the inducible isoform of cycloxygenase enzyme family that catalyzes synthesis of inflammatory mediators, prostanoids and prostaglandins, and therefore, can be targeted by anti-inflammatory drugs. Here, we showed a plant polyphenol, kaempferol, attenuated IL-6-induced COX-2 expression in human monocytic THP-1 cells suggesting its beneficial role in chronic inflammation. Kaempferol deactivated and prevented nuclear localization of two major transcription factors STAT3 and NF-κB, mutually responsible for COX-2 induction in response to IL-6. Moreover, STAT3 and NF-κB were simultaneously deactivated by kaempferol in acute inflammation, as shown by carrageenan-induced mouse paw edema model. The concomitant reduction in COX-2 expression in paw tissues suggested kaempferol's role in mitigation of inflammation by targeting STAT3 and NF-κB.

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