Abstract Title:

Protective effect of stress-induced liver damage by saponin fraction from Codonopsis lanceolata.

Abstract Source:

Arch Pharm Res. 2009 Oct;32(10):1441-6. Epub 2009 Nov 8. PMID: 19898808

Abstract Author(s):

Min Ho Kim, Jaehwi Lee, Dae Sung Yoo, Yong Gyu Lee, Se Eun Byeon, Eock Kee Hong, Jae Youl Cho

Article Affiliation:

School of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Korea.


Saponins are valuable principles found in various herbal medicine with pharmaceutical, cosmetical and nutraceutical merits. In this study, we evaluated the protective role of saponin fraction (Cl-SF), prepared from Codonopsis lanceolata, an ethnopharmacologically famous plant in Korea, China and Japan, on water immersion stress-induced liver damage and radical generation. Cl-SF clearly decreased the up-regulated levels of serum glutamate-oxalacetate transaminase and glutamate-pyruvate-transaminase induced by water-immersed stress conditions. Furthermore, Cl-SF seemed to block the stress-induced radicals. Thus, Griess and DPPH assays revealed that Cl-SF significantly suppressed both radical generation in sodium nitroprusside-treated RAW264.7 cells and nitric oxide production in LPS-treated RAW264.7 cells. Therefore, these results suggest that Cl-SF may be considered as a promising stress-regulatory principle with radical scavenging actions.

Study Type : Animal Study

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