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Article Publish Status: FREE
Abstract Title:

Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death.

Abstract Source:

Oncotarget. 2015 Aug 14 ;6(23):19514-27. PMID: 26098775

Abstract Author(s):

Stefania Raimondo, Flores Naselli, Simona Fontana, Francesca Monteleone, Alessia Lo Dico, Laura Saieva, Giovanni Zito, Anna Flugy, Mauro Manno, Maria Antonietta Di Bella, Giacomo De Leo, Riccardo Alessandro

Article Affiliation:

Stefania Raimondo

Abstract:

Nanosized vesicles are considered key players in cell to cell communication, thus influencing physiological and pathological processes, including cancer. Nanovesicles have also been found in edible-plants and have shown therapeutic activity in inflammatory bowel diseases; however information on their role in affecting cancer progression is missing.Our study identify for the first time a fraction of vesicles from lemon juice (Citrus limon L.), obtained as a result of different ultracentrifugation, with density ranging from 1,15 to 1,19 g/ml and specific proteomic profile. By using an in vitro approach, we show that isolated nanovesicles inhibit cancer cell proliferation in different tumor cell lines, by activating a TRAIL-mediated apoptotic cell death. Furthermore, we demonstrate that lemon nanovesicles suppress CML tumor growth in vivo by specifically reaching tumor site and by activating TRAIL-mediated apoptotic cell processes. Overall, this study suggests the possible use of plant-edible nanovesicles as a feasible approach in cancer treatment.

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