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Abstract Title:

Chrysin suppress immune responses and protects from experimental autoimmune encephalomyelitis in mice.

Abstract Source:

J Neuroimmunol. 2019 Oct 15 ;335:577007. Epub 2019 Jul 16. PMID: 31376787

Abstract Author(s):

Lucian Del Fabbro, Marcelo Gomes de Gomes, Leandro Cattelan Souza, André Rossito Goes, Silvana Peterini Boeira, Mauro Schneider Oliveira, Ana Flávia Furian, Cristiano Ricardo Jesse

Article Affiliation:

Lucian Del Fabbro

Abstract:

We investigated the effects of chrysin in the experimental autoimmune encephomyelitis (EAE), a multiple sclerosis (MS) animal model. EAE was induced using myelin oligodendrocyte glycoprotein (MOG) 35-55 peptide in C57BL/6 mice. Chrysin reduced weight loss, attenuated clinical signs and blunted the EAE-induced increase in histone deacetylase (HDCA) activity, glycogen synthase kinase-3β (GSK-3β) levels and pro-inflammatory cytokine levels as well as in the EAE-induced decrease in histone acetyltransferases 3 and 4 (HAT3, HAT4). Altogether, results demonstrate beneficial effects and potential targets of chrysin in EAE.

Study Type : Animal Study

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