n/a
Article Publish Status: FREE
Abstract Title:

Gamma-oryzanol Prevents LPS-induced Brain Inflammation and Cognitive Impairment in Adult Mice.

Abstract Source:

Nutrients. 2019 Mar 29 ;11(4). Epub 2019 Mar 29. PMID: 30934852

Abstract Author(s):

Andrea Mastinu, Sara Anna Bonini, Wiramon Rungratanawanich, Francesca Aria, Mariagrazia Marziano, Giuseppina Maccarinelli, Giulia Abate, Marika Premoli, Maurizio Memo, Daniela Uberti

Article Affiliation:

Andrea Mastinu

Abstract:

BACKGROUND: Rice (L.) is the main food source for more than half of humankind. Rice is rich in phytochemicals and antioxidants with several biological activities; among these compounds, the presence ofγ-oryzanol is noteworthy. The present study aims to explore the effects of γ-oryzanol on cognitive performance in a mouse model of neuroinflammation and cognitive alterations.

METHODS: Mice received 100 mg/kgγ-oryzanol (ORY) or vehicle once daily for 21 consecutive days and were then exposed to an inflammatory stimulus elicited by lipopolysaccharide (LPS). A novel object recognition test and mRNA expression of antioxidant and neuroinflammatory markers in the hippocampus were evaluated.

RESULTS: ORY treatment was able to improve cognitive performance during the neuroinflammatory response. Furthermore, phase II antioxidant enzymes such as heme oxygenase-1 (HO-1) and NADPH-dehydrogenase-quinone-1 (NQO1) were upregulated in the hippocampi of ORY and ORY+LPS mice. Lastly,γ-oryzanol showed a strong anti-inflammatory action by downregulating inflammatory genes after LPS treatment.

CONCLUSION: These results suggest that chronic consumption ofγ-oryzanol can revert the LPS-induced cognitive and memory impairments by promoting hippocampal antioxidant and anti-inflammatory molecular responses.

Print Options


Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.