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Abstract Title:

Chronic anterior uveitis following bacille Calmette-Guérin vaccination: molecular mimicry in action?

Abstract Source:

J Pediatr Ophthalmol Strabismus. 2008 Jul-Aug;45(4):252-3. PMID: 18705627

Abstract Author(s):

Alexander Spratt, Tim Key, Anthony J Vivian

Article Affiliation:

Alexander Spratt

Abstract:

A 13-year-old girl developed bilateral chronic anterior uveitis following bacille Calmette-Guérin (BCG) vaccination. HLA testing was negative for B27 but positive for DRB1 *0404, a variant of DR4 often associated with rheumatoid arthritis. The authors propose her HLA repertoire allowed for a BCG-induced abnormal autoimmune response by the mechanism of molecular mimicry.

Study Type : Human: Case Report

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Sayer Ji
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