n/a
Article Publish Status: FREE
Abstract Title:

Chlorogenic Acid Promotes Autophagy and AlleviatesTyphimurium Infection Through the lncRNAGAS5/miR-23a/PTEN Axis and the p38 MAPK Pathway.

Abstract Source:

Front Cell Dev Biol. 2020 ;8:552020. Epub 2020 Nov 5. PMID: 33240872

Abstract Author(s):

Shirui Tan, Fang Yan, Qingrong Li, Yaping Liang, Junxu Yu, Zhenjun Li, Feifei He, Rongpeng Li, Ming Li

Article Affiliation:

Shirui Tan

Abstract:

Background: ) causes several intestinal diseases. Polyphenols including chlorogenic acid (CGA) inhibit pathogenesis.

Objective: This study aimed to investigate the mechanisms of CGA ininfection.

Methods: The intestinal pathological changes and survival rate of ST-infected mice were measured to verify the protection of CGA oninfection. The antibacterial effects of CGAon the invasion to intestinal epithelial cells and autophagy was evaluated. The relationships among GAS5, miR-23a, and PTEN were verified. Expression of inflammation- and autophagy-related proteins was detected.

Results: CGA treatment alleviated pathological damage, improved the secretion disturbance of intestinal cytokines caused byinfection, and reduced the mortality of mice. Intestinal GAS5 was upregulated after CGA treatment. LncRNA GAS5 competitively bound to miR-23a to upregulate PTEN and inhibit the p38 MAPK pathway. CGA regulated the p38 MAPK pathway through lncRNA GAS5/miR-23a/PTEN axis to promote autophagy ininfection. The functional rescue experiments of miR-23a and PTEN further identified these effects.

Conclusion: CGA promotes autophagy and inhibitsinfection through the GAS5/miR-23a/PTEN axis and the p38 MAPK pathway.

Study Type : In Vitro Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.