Abstract Title:

Long-term effects of calorie restriction on serum sex-hormone concentrations in men.

Abstract Source:

Aging Cell. 2010 Apr;9(2):236-42. Epub 2010 Jan 20. PMID: 20096034

Abstract Author(s):

Roberto Cangemi, Alberto J Friedmann, John O Holloszy, Luigi Fontana

Article Affiliation:

Center for Human Nutrition, Washington University School of Medicine, St. Louis, MO, USA.

Abstract:

Calorie restriction (CR) slows aging and consistently reduces circulating sex hormones in laboratory animals. However, nothing is known regarding the long-term effects of CR with adequate nutrition on serum sex-hormone concentration in lean healthy humans. In this study, we measured body composition, and serum total testosterone, total 17-beta-estradiol, sex hormone-binding globulin (SHBG), and dehydroepiandrosterone sulfate (DHEA-S) concentrations in 24 men (mean age 51.5 +/- 13 years), who had been practicing CR with adequate nutrition for an average of 7.4 +/- 4.5 years, in 24 age- and body fat-matched endurance runners (EX), and 24 age-matched sedentary controls eating Western diets (WD). We found that both the CR and EX volunteers had significantly lower body fat than the WD volunteers (total body fat, 8.7 +/- 4.2%; 10.5 +/- 4.4%; 23.2 +/- 6.1%, respectively; P = 0.0001). Serum total testosterone and the free androgen index were significantly lower, and SHBG was higher in the CR group than in the EX and WD groups (P

Study Type : Human Study

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