Article Publish Status: FREE
Abstract Title:

Modulation of Tamoxifen Cytotoxicity by Caffeic Acid Phenethyl Ester in MCF-7 Breast Cancer Cells.

Abstract Source:

Oxid Med Cell Longev. 2016 ;2016:3017108. Epub 2015 Nov 30. PMID: 26697130

Abstract Author(s):

Tarek K Motawi, Samy A Abdelazim, Hebatallah A Darwish, Eman M Elbaz, Samia A Shouman

Article Affiliation:

Tarek K Motawi

Abstract:

Although Tamoxifen (TAM) is one of the most widely used drugs in managing breast cancer, many women still relapse after long-term therapy. Caffeic acid phenethyl ester (CAPE) is a polyphenolic compound present in many medicinal plants and in propolis. The present study examined the effect of CAPE on TAM cytotoxicity in MCF-7 cells. MCF-7 cells were treated with different concentrations of TAM and/or CAPE for 48 h. This novel combination exerted synergistic cytotoxic effects against MCF-7 cells via induction of apoptotic machinery with activation of caspases and DNA fragmentation, along with downregulation of Bcl-2 and Beclin 1 expression levels. However, the mammalian microtubule-associated protein light chain LC 3-II level was unchanged. Vascular endothelial growth factor level was also decreased, whereas levels of glutathione and nitric oxide were increased. In conclusion, CAPE augmented TAM cytotoxicity via multiple mechanisms, providing a novel therapeutic approach for breast cancer treatmentthat can overcome resistance and lower toxicity. This effect provides a rationale for further investigation of this combination.

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