Abstract Title:

The effect of curcumin on cadmium-induced oxidative damage and trace elements level in the liver of rats and mice.

Abstract Source:

Acta Neurol Scand Suppl. 1994;154:32-41. PMID: 15177643

Abstract Author(s):

Vladislav Eybl, Dana Kotyzová, Monika Bludovská

Article Affiliation:

Department of Pharmacology and Toxicology, Faculty of Medicine in Pilsen, Charles University in Prague, Karlovarská 48, 301 66 Pilsen, Czech Republic. vladislav.eybl@lfp.cuni.cz

Abstract:

The present study was designed to investigate in acute animal experiments the effects of oral curcumin pre-treatment (50 mg/kg body weight per day for 3 days) on liver oxidative damage and trace element changes caused by cadmium chloride administration (0.025 mmol/kg to rats and 0.03 mmol/kg to mice, s.c., 1h after the last curcumin treatment). In rats, the level of Cd-induced lipid peroxidation (320% of controls) was significantly lowered by curcumin pre-treatment (165% of controls), and was accompanied by significant increase of glutathione (GSH) level in both Cd-treated and Cd plus curcumin-treated group. In mice, the Cd-induced lipid peroxidation (125% of controls) was abolished by curcumin treatment. Concurrently, a depletion of GSH was found in the liver of both Cd-treated (67% of controls) and Cd plus curcumin-treated mice (54% of controls). Curcumin treatment did not change cadmium (Cd) distribution and did not cause systematic alterations in trace element status.

Study Type : Animal Study

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