Article Publish Status: FREE
Abstract Title:

Mechanism of growth inhibitory effect of Blumea balsamifera extract in hepatocellular carcinoma.

Abstract Source:

Biosci Biotechnol Biochem. 2008 May ;72(5):1183-9. Epub 2008 May 7. PMID: 18460811

Abstract Author(s):

Toshio Norikura, Akiko Kojima-Yuasa, Miki Shimizu, Xuedan Huang, Shenghui Xu, Saeda Kametani, Sook-Nyung Rho, David Opare Kennedy, Isao Matsui-Yuasa

Article Affiliation:

Toshio Norikura

Abstract:

Blumea balsamifera is known to improve physiological disorders such as rheumatism and hypertension, but its anticancer activity has not been well elucidated. In this study, we found that Blumea balsamifera MeOH extract (BME) induced growth-inhibitory activity in rat and human hepatocellular carcinoma cells without cytotoxicity in rat hepatocytes which were used as a normal cell model. BME induced cell cycle arrest at the G1 phase via decreases in the expression of cyclin-E and phosphorylation of retinoblastoma protein. Furthermore, BME reduced the level of a proliferation-inducing ligand, that stimulates tumor cell growth. These findings suggest that BME has possible therapeutic potential in hepatoma cancer patients and that depletion of cellular APRIL is an important mechanism in the growth-inhibitory effect of BME.

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