n/a
Abstract Title:

Bisphenol S modulates concentrations of bisphenol A and oestradiol in female and male mice.

Abstract Source:

Xenobiotica. 2018 May 23:1-35. Epub 2018 May 23. PMID: 29790806

Abstract Author(s):

Tyler Pollock, Lucas J Greville, Rachel E Weaver, Marija Radenovic, Denys deCatanzaro

Article Affiliation:

Tyler Pollock

Abstract:

1. Concern over endocrine-disrupting actions of bisphenol A (BPA) has prompted some manufacturers to remove it from consumer products. Among the chemical replacements in 'BPA-free' products are other bisphenol analogues, such as bisphenol S (BPS). Given evidence that BPA and BPS possess similar oestrogenic activity, their capacity to interact and disrupt oestrogen homeostasis should be examined. 2. We investigated whether BPS can modulate concentrations ofC-BPA, exogenousH-oestradiol (E2), or natural E2. CF-1 mice were each given a single subcutaneous injection of oil containing 0 (vehicle), 1, 3, or 9 mg BPS, then given a dietary supplement containing either 50 μg/kgC-BPA or 5μCi (14.5 ng)H-E2. BPS treatment elevatedC-BPA concentrations in blood serum and certain reproductive organs of both sexes, but reducedH-E2 concentrations in blood serum of females. In another experiment, natural E2 was measured in urine 2-12 h after injection of 0 (vehicle), 1, or 3 mg BPS. BPS reduced E2 concentrations at 10 h after injection in both sexes. 3. These results are consistent with evidence that BPS and BPA compete for access to metabolic enzymes, and that BPS can disrupt oestrogen homeostasis. These findings demonstrate the importance of considering multiple toxicants when determining regulatory exposure limits.

Study Type : Animal Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.