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Abstract Title:

Bisphenol A exposure is involved in the development of Parkinson like disease in Drosophila melanogaster.

Abstract Source:

Food Chem Toxicol. 2020 Jan 14 ;137:111128. Epub 2020 Jan 14. PMID: 31952986

Abstract Author(s):

Elize Aparecida Santos Musachio, Stífani Machado Araujo, Vandreza Cardoso Bortolotto, Shanda de Freitas Couto, Mustafa Munir Mustafa Dahleh, Marcia Rósula Poetini, Eliana Fernandes Jardim, Luana Barreto Meichtry, Bruna Piaia Ramborger, Rafael Roehrs, Gustavo Petri Guerra, Marina Prigol

Article Affiliation:

Elize Aparecida Santos Musachio

Abstract:

The pathogenesis of Parkinson's disease has not been fully clarified yet but its cause is known to be multifactorial. One of these factors is oxidative stress induced by exposure to environmental toxifiers. We studied the effect of Bisphenol A (BPA) at concentrations of 0.5 mM and 1 mM, the concentration of 1 mM corresponding to Lowest Observed Adverse Effect Level (LOAEL) for humans in adult Drosophila melanogaster. The BPA induced oxidative stress was established by increased levels of malondialdehyde, reactive species, and decreased activity of the antioxidant enzymes superoxide dismutase and catalase, and detoxificant enzyme glutathione-S-transferase. Associated with oxidative stress, there was a reduction of acetylcholinesterase activity and a reduction of dopamine levels, which are related to the decreased locomotion activity as observed in negative geotaxis, open field and equilibrium behaviors in group exposed to 1 mM of BPA. Oxidative stress also impaired mitochondrial and cellular metabolic activity in the head causing an increase in the mortality of flies exposed to both BPA concentrations. Therefore, BPA induced Parkinsonian-like changes inflies and it is possible that the oxidative stress is closely related to this effect, providing new insights for future studies.

Study Type : Insect Study

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