n/a
Abstract Title:

Bisphenol-A exposure during gestation and lactation causes visual perception deficits in rat pups following a decrease in IL-1β expression in the primary visual cortex.

Abstract Source:

Neuroscience. 2020 Mar 25. Epub 2020 Mar 25. PMID: 32222558

Abstract Author(s):

Fan Hu, Linke Zhang, Tingting Li, Huan Wang, Weifeng Liang, Yifeng Zhou

Article Affiliation:

Fan Hu

Abstract:

Bisphenol-A (BPA) exposure can affect cognitive functions of rodents and humans. However, whether information inputs for these functions in the brain are perturbed by BPA remains unclear. Here, visual perception in rats was assessed by testing their ability to discriminate between vertical and horizontal grating. We found that BPA exposure (1 mg/kg/day) during gestation and lactation markedly decreased the grating discrimination ability in rat pups (postnatal 21 days). The results of neuronal functions in the primary visual cortex (V1) showed that the orientation selectivity and signal extraction ability and fidelity were notably decreased after BPA exposure. These effects were accompanied by a reduction in synaptic plasticity (i.e., spine density and maturity) in the V1. According to inflammatory factor expression and glial cell morphology, no increase in inflammatory activation was observed after BPA exposure. However, BPA-exposed rat pups exhibited a significant decrease in IL-1β expression in the V1, accompanied by a decline in P38 phosphorylation. After local injection of IL-1β (10 ng/ml) in the V1, these two visual properties recovered to normal levels. Thus, our findings imply that physiological dysfunction of IL-1β may contribute to orientation perception deficitsin BPA-exposed rats.

Study Type : Animal Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.