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Abstract Title:

Biphenyl-type neolignans from stem bark of Magnolia officinalis with potential anti-tumor activity.

Abstract Source:

Fitoterapia. 2020 Nov 2:104769. Epub 2020 Nov 2. PMID: 33152462

Abstract Author(s):

Heng-Fan Ni, Xiaoying Cai, Xiang Qiu, Lin Liu, Xu Ma, Li Wan, Haoyu Ye, Lijuan Chen

Article Affiliation:

Heng-Fan Ni

Abstract:

Six new biphenyl-type neolignans (1-6), and eighteen known compounds (7-24) were isolated from the EtOH extract of Magnolia officinalis. Their structures were determined by 1D and 2D NMR, and by HRMS. The anti-tumor activities of the isolated compounds were evaluated on HepG2, HCT-116, H1975 and HUVEC cell lines. Among the isolated compounds, nine compounds (3, 5, 7, 8, 12, 14, 20, 22, and 24) showed moderate cytotoxicities, and compound 23 showed the best cytotoxicity with ICvalue lower than 10 μM.

Study Type : In Vitro Study

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