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Article Publish Status: FREE
Abstract Title:

BG-4 from Bitter Gourd () Differentially Affects Inflammation In Vitro and In Vivo.

Abstract Source:

Antioxidants (Basel). 2019 Jun 14 ;8(6). Epub 2019 Jun 14. PMID: 31197086

Abstract Author(s):

Andrea Nieto-Veloza, Zhihong Wang, Qixin Zhong, Hari B Krishnan, Vermont P Dia

Article Affiliation:

Andrea Nieto-Veloza

Abstract:

BG-4 isolated from bitter gourd has been reported for anti-cancer properties. The objective was to evaluate the anti-inflammatory properties of BG-4 in vitro and in vivo. Comparative study of the anti-inflammatory properties of BG-4 in vitro and in vivo was conducted on lipopolysaccharide (LPS)-activated mouse macrophages, and on dextran sodium sulfate (DSS)-induced colitis in mice. BG-4 reduced the production of pro-inflammatory markers in LPS-activated macrophages. On the other hand, intraperitoneal administration of BG-4 in DSS-induced colitis led to colon shortening, elevated neutrophils infiltration and myeloperoxidase activity, presence of blood in the stool, and loss of body weight, with differential systemic and local effects on pro-inflammatory cytokines in vivo. The results demonstrated that BG-4 differentially affected inflammation in vitro and in vivo.

Study Type : Animal Study, In Vitro Study

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