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Article Publish Status: FREE
Abstract Title:

Beta-caryophyllene enhances wound healing through multiple routes.

Abstract Source:

PLoS One. 2019 ;14(12):e0216104. Epub 2019 Dec 16. PMID: 31841509

Abstract Author(s):

Sachiko Koyama, Anna Purk, Manpreet Kaur, Helena A Soini, Milos V Novotny, Keith Davis, C Cheng Kao, Hiroaki Matsunami, Anthony Mescher

Article Affiliation:

Sachiko Koyama

Abstract:

Beta-caryophyllene is an odoriferous bicyclic sesquiterpene found in various herbs and spices. Recently, it was found that beta-caryophyllene is a ligand of the cannabinoid receptor 2 (CB2). Activation of CB2 will decrease pain, a major signal for inflammatory responses. We hypothesized that beta-caryophyllene can affect wound healing by decreasing inflammation. Here we show that cutaneous wounds of mice treated with beta-caryophyllene had enhanced re-epithelialization. The treated tissue showed increased cell proliferation and cells treated with beta-caryophyllene showed enhanced cell migration, suggesting that the higher re-epithelialization is due to enhanced cell proliferation and cell migration. The treated tissues also had up-regulated gene expression for hair follicle bulge stem cells. Olfactory receptors were not involved in the enhanced wound healing. Transient Receptor Potential channel genes were up-regulated in the injured skin exposed to beta-caryophyllene. Interestingly, there were sex differences in the impact of beta- caryophyllene as only the injured skin of female mice had enhanced re-epithelialization after exposure to beta-caryophyllene. Our study suggests that chemical compounds included in essential oils have the capability to improve wound healing, an effect generated by synergetic impacts of multiple pathways.

Study Type : Animal Study

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