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Abstract Title:

Berberine: A novel therapeutic strategy for cancer.

Abstract Source:

IUBMB Life. 2020 Jul 31. Epub 2020 Jul 31. PMID: 32735398

Abstract Author(s):

Parisa Samadi, Parisa Sarvarian, Elham Gholipour, Karim Shams Asenjan, Leili Aghebati-Maleki, Roza Motavalli, Mohammad Hojjat-Farsangi, Mehdi Yousefi

Article Affiliation:

Parisa Samadi

Abstract:

Cancer, even currently, is one of the main reasons for mortality and morbidity, worldwide. In recent years, a great deal of effort has been made to find efficient therapeutic strategies for cancer, however, particularly with regards to side effects and the possibility of complete remission. Berberine (BBR) is a nature-driven phytochemical component originated from different plant groups such as Berberis vulgaris, Berberis aquifolium, and Berberis aristata. BBR is a well-known nutraceutical because of its wide range of pharmacological activities including anti-inflammatory, antidiabetic, antibacterial, antiparasitic, antidiarrheal, antihypertensive, hypolipidemic, and fungicide. In addition, it exhibits inhibitory effects on multiple types of cancers. In this review, we have elaborated on the anticancer effects of BBR through the regulation of different molecular pathways such as: inducing apoptosis, autophagy, arresting cell cycle, and inhibiting metastasis and invasion.

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