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Article Publish Status: FREE
Abstract Title:

In vitro and in vivo antitumor evaluation of berbamine for lung cancer treatment.

Abstract Source:

Asian Pac J Cancer Prev. 2014 ;15(4):1767-9. PMID: 24641406

Abstract Author(s):

Zhi-Bo Hou, Kai-Jin Lu, Xiao-Li Wu, Cong Chen, Xin-En Huang, Hai-Tao Yin

Article Affiliation:

Zhi-Bo Hou

Abstract:

PURPOSE: Lung cancer, one of the most frequently diagnosed cancers in the world, is characterized by relatively high morbidity and mortality. Berbamine (BER) has been initially reported to exert anti-proliferative effects against a series of cancers.

METHODS: In this study the in vitro cytotoxicity of BER was measured by MTT assay. In vivo anti-cancer efficacy of BER was assessed in A549 xenografts.

RESULTS: Cytotoxicity tests showed dose-dependent cell growth inhibition effects of BER against A549 cells. Moreover, BER significantly reduced the growth of lung cancer in a dose-dependent manner in nude mice with prolonged survival time.

CONCLUSION: Therefore, BER might be in herbal medicine for cancer therapy and further efforts are needed to explore therapeutic strategies.

Study Type : Animal Study, In Vitro Study

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Sayer Ji
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