Article Publish Status: FREE
Abstract Title:

Effect of vitamin C and vitamin E on lung contusion: A randomized clinical trial study.

Abstract Source:

Ann Med Surg (Lond). 2018 Dec ;36:152-157. Epub 2018 Nov 9. PMID: 30479762

Abstract Author(s):

Davoodabadi Abdoulhossein, Iman Taheri, Mohammad Ali Saba, Hossein Akbari, Shima Shafagh, Asemi Zataollah

Article Affiliation:

Davoodabadi Abdoulhossein


: There is association between lung contusion (lC) and a progressive inflammatory response. The protective effect of vitamin C and vitamin E, as strong free radical scavengers on favourite outcome of (LC) in animal models, has been confirmed.

Design: to evaluate the effect of vitamins, E and C on arterial blood gas (ABG) and ICU stay, in (LC), with injury severity score (ISS) 18 ± 2, due to blunt chest trauma.

Methods: This study was a randomized, double-blind, placebo-controlled clinical trial. Patients with (ISS) 18 ± 2 blunt chest trauma, who meet criteria, participated in the study. A total of 80 patients from Feb 2015 to Jun2018and were randomly divided into 4 groups. Patients received intravenous vitamin E (1000IU mg), was (group I); intravenous vitamin C (500) (group II). Vitamin C + vitamin E = (group III), and intravenous distilled water = (control group) or (group IV). ABG, serum cortisol, and CRP levels were determined at baseline, 24 h and 48 h after the intervention.

Results: a significant decrease in ICU stay in group III compared to other groups (p < 0.001). Co-administration of vitamin C and vitamin E showed significant increases pH (values to reference range from acidemia"), oxygen pressure, and oxygen saturation in group III compared to other groups (p < 0.001). A significant decrease in carbon dioxide pressure was also detected after receiving vitamin C and vitamin E in group III, compared to other groups (p < 0.001). There was no significant difference cortisol and CRP levels between groups after the intervention.

Conclusion: Co-administration of vitamin C and vitamin E, improve the ABG parameters and reduce ICU stay.

Study Type : Human Study

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