Abstract Title:

Essential oils of commonly used plants as inhibitors of peroxynitrite-induced tyrosine nitration.

Abstract Source:

Fitoterapia. 2005 Jul;76(5):481-3. PMID: 15967593

Abstract Author(s):

Silvio Chericoni, Josè M Prieto, Patrizia Iacopini, Ivano Morelli

Article Affiliation:

Dipartimento di Chimica Bioorganica e Biofarmacia, Università di Pisa, via Bonanno 33, 56126 Pisa, Italy. chersil@farm.unipi.it

Abstract:

The essential oils obtained from fifteen relevant and commonly used plants belonging to Cruciferae, Lamiaceae, Lauraceae, Apiaceae, and Zingiberaceae were screened using an in vitro model of peroxynitrite-induced tyrosine nitration. Almost complete inhibition of 3-nitrotyrosine formation (91% at 300 microg/ml) was achieved only with the essential oil obtained from the leaves of Laurus nobilis. 1,8-Cineol, accounting for a 50% of this essential oil, which resulted as inactive in this model, thus evidencing a major role for the minor volatile compounds present in the leaves.

Study Type : In Vitro Study

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