Article Publish Status: FREE
Abstract Title:

Autism Spectrum Disorder (ASD) with and without Mental Regression is Associated with Changes in the Fecal Microbiota.

Abstract Source:

Nutrients. 2019 Feb 5 ;11(2). Epub 2019 Feb 5. PMID: 30764497

Abstract Author(s):

Julio Plaza-Díaz, Antonio Gómez-Fernández, Natalia Chueca, María José de la Torre-Aguilar, Ángel Gil, Juan Luis Perez-Navero, Katherine Flores-Rojas, Pilar Martín-Borreguero, Patricio Solis-Urra, Francisco Javier Ruiz-Ojeda, Federico Garcia, Mercedes Gil-Campos

Article Affiliation:

Julio Plaza-Díaz


New microbiome sequencing technologies provide novel information about the potential interactions among intestinal microorganisms and the host in some neuropathologies as autism spectrum disorders (ASD). The microbiota⁻gut⁻brain axis is an emerging aspect in the generation of autistic behaviors; evidence from animal models suggests that intestinal microbial shifts may produce changes fitting the clinical picture of autism. The aim of the present study was to evaluate the fecal metagenomic profiles in childrenwith ASD and compare them with healthy participants. This comparison allows us to ascertain how mental regression (an important variable in ASD) could influence the intestinal microbiota profile. For this reason, a subclassification in children with ASD by mental regression (AMR) and no mental regression (ANMR) phenotype was performed. The present report was a descriptive observational study. Forty-eight children aged 2⁻6 years with ASD were included: 30 with ANMR and 18 with AMR. In addition, a control group of 57 normally developing children was selected and matched to the ASD group by sex and age. Fecal samples were analyzed with a metagenomic approach using a next-generation sequencing platform. Several differences between children with ASD, compared with the healthy group, were detected. Namely,andat phylum level, as well as,,, andat class level were found at higher proportions in children with ASD. Additionally,levels showed to be augmented exclusively in AMR children. Preliminary results, using a principal component analysis, showed differential patterns in children with ASD, ANMR and AMR, compared to healthy group, both for intestinal microbiota and food patterns. In this study, we report, higher levels of,and, aside from, andin children with ASD compared to healthy group. Furthermore, AMR children exhibited higher levels of. Further analysis using these preliminary results and mixing metagenomic and other"omic"technologies are needed in larger cohorts of children with ASD to confirm these intestinal microbiota changes.

Study Type : Human Study

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