Abstract Title:

Atorvastatin treatment reduces exercise capacities in rats: Involvement of mitochondrial impairments and oxidative stress.

Abstract Source:

J Appl Physiol. 2011 Aug 18. Epub 2011 Aug 18. PMID: 21852406

Abstract Author(s):

Jamal Bouitbir, Anne-Laure Charles, Laurence Rasseneur, Stéphane P Dufour, Francois Piquard, Bernard Geny, Joffrey Zoll

Article Affiliation:

1Hopitaux Universitaires.


Physical exercise exacerbates the cytotoxic effects of statins in skeletal muscle. Mitochondrial impairments may play an important role in the development of muscular symptoms following statin treatment. Our objective was to characterize mitochondrial function and reactive oxygen species (ROS) production in skeletal muscle after exhaustive exercise in atorvastatin-treated rats. The animals were divided into four groups: resting control (CONT, n=8) and exercise rats (CONT+EXE, n=8) as well as resting (ATO, n=10) and exercise (ATO+EXE, n=8) rats that were treated with atorvastatin (10 mg/kg/day for two weeks). Exhaustive exercise showed that the distance that was covered by treated animals was reduced (P<0.05). Using dihydroethidium staining, we showed that the ROS level was increased by 60 % in the plantaris muscle of ATO compared to CONT rats and was highly increased in ATO+EXE (+226 %) compared to that in CONT+EXE rats. The maximal mitochondrial respiration (V(max)) was decreased in ATO rats compared to that in CONT rats (P<0.01). In CONT+EXE rats, V(max) significantly increased compared to those in CONT rats (P<0.05). V(max) was significantly lower in ATO+EXE rats (-39 %) compared to that in CONT+EXE rats (P<0.001). The distance that was covered by rats significantly correlated with V(max) (r=0.62, P<0.01). The glycogen content was decreased in ATO , CONT+EXE and ATO+EXE rats compared to that in CONT rats (P<0.05). GLUT-4 mRNA expression was higher after exhaustive exercise in CONT+EXE rats compared to the other groups (P<0.05). Our results show that exhaustive exercise exacerbated metabolic perturbations and ROS production in skeletal muscle, which may reduce the exercise capacity and promote the muscular symptoms in sedentary atorvastatin-treated animals.

Study Type : Animal Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.