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Article Publish Status: FREE
Abstract Title:

Astilbin fromRoxb. Attenuates Inflammatory Responses in Complete Freund's Adjuvant-Induced Arthritis Rats.

Abstract Source:

Evid Based Complement Alternat Med. 2017 ;2017:8246420. Epub 2017 Aug 22. PMID: 29104606

Abstract Author(s):

Lisha Dong, Jinqiu Zhu, Hongzhi Du, Heng Nong, Xicheng He, Xiaoyu Chen

Article Affiliation:

Lisha Dong

Abstract:

Astilbin, a flavonoid compound, was isolated from the rhizome ofRoxb. (with red cross-section) grown in Guizhou Province, China. We accessed its effect and potential mechanism on attenuation of the inflammatory response in CFA-induced AA rats. Our results showed that daily oral administration of astilbin at 5.3 mg/kg reduced joint damage in the hind paw of AA rats. Accordingly, astilbin exhibited remarkable inhibitory effects on TNF-, IL-1, and IL-6 mRNA expression. Significant decrease of serum cytokine levels of TNF-, IL-1, and IL-6 was also observed in astilbin-treated AA rats compared to the vehicle-treated AA rats. The reduced expression of these cytokines was associated with protein activity suppression of three key molecular targets in the pathogenesis of RA, including IKK, NF-B p65 subunit, and TLR adaptor MyD88. Furthermore, the therapeutic effects of astilbin on the inhibition of cytokines production as well as the reduction of inflammatory response in AA rats are close to a commonly used antirheumatic drug, leflunomide. Collectively, our data suggest that the action mechanism of astilbin, as an anti-inflammatory agent for RA treatment, is associated with modulating the production of proinflammatory cytokines and inhibiting the expression of key elements in NF-B signaling pathway mediated by TLR.

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