Abstract Title:

Ascorbic acid and beta-carotene reduce stress-induced oxidative organ damage in rats.

Abstract Source:

Biotech Histochem. 2016 Sep 14:1-10. Epub 2016 Sep 14. PMID: 27629436

Abstract Author(s):

M Esrefoglu, A Akinci, E Taslidere, H Elbe, A Cetin, B Ates

Article Affiliation:

M Esrefoglu


Antioxidants are potential therapeutic agents for reducing stress-induced organ damage. We investigated the effects of ascorbic acid andβ-carotene on oxidative stress-induced cerebral, cerebellar, cardiac and hepatic damage using microscopy and biochemistry. Male Wistar albino rats were divided into five groups: untreated control, stressed, stressed + saline, stressed + ascorbic acid and stressed + β-carotene. The rats in the stressed groups were subjected to starvation, immobilization and cold. The histopathological damage scores for the stressed and stressed + saline groups were higher than those of the control group for all organs examined. The histopathological damage scores and mean tissue malondialdehyde levels for thegroups treated with antioxidants were lower than those for the stressed and stressed + saline groups. Mean tissue superoxide dismutase activities for groups that received antioxidants were higher than those for the stressed + saline group for most organs evaluated. Ascorbic acid and β-carotene canreduce stress-induced organ damage by both inhibiting lipid oxidation and supporting the cellular antioxidant defense system.

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Sayer Ji
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