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Article Publish Status: FREE
Abstract Title:

Sodium ascorbate kills Candida albicans in vitro via iron-catalyzed Fenton reaction: importance of oxygenation and metabolism.

Abstract Source:

Future Microbiol. 2016 12 ;11:1535-1547. Epub 2016 Nov 18. PMID: 27855492

Abstract Author(s):

Pinar Avci, Fernanda Freire, Andras Banvolgyi, Eleftherios Mylonakis, Norbert M Wikonkal, Michael R Hamblin

Article Affiliation:

Pinar Avci

Abstract:

AIM: Ascorbate can inhibit growth and even decrease viability of various microbial species including Candida albicans. However the optimum conditions and the mechanism of action are unclear. Materials/methodology: Candida albicans shaken for 90 min in a buffered solution of ascorbate (90 mM) gave a 5-log reduction of cell viability, while there was no killing without shaking, in growth media with different carbon sources or at 4°C. Killing was inhibited by the iron chelator 2,2'-bipyridyl. Hydroxyphenyl fluorescein probe showed the intracellular generation of hydroxyl radicals.

RESULTS/CONCLUSION: Ascorbate-mediated killing of C. albicans depends on oxygenation and metabolism, involves iron-catalyzed generation of hydroxyl radicals via Fenton reaction and depletion of intracellular NADH. Ascorbate could serve as a component of a topical antifungal therapy.

Study Type : In Vitro Study

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Sayer Ji
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