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Article Publish Status: FREE
Abstract Title:

Protective Role of Apigenin Against Aβ 25-35 Toxicity Via Inhibition of Mitochondrial Cytochrome c Release.

Abstract Source:

Basic Clin Neurosci. 2019 Nov-Dec;10(6):557-566. Epub 2019 Nov 1. PMID: 32477473

Abstract Author(s):

Farnaz Nikbakht, Yasaman Khadem, Sobhan Haghani, Hadiseh Hoseininia, Alireza Moein Sadat, Paria Heshemi, Nida Jamali

Article Affiliation:

Farnaz Nikbakht

Abstract:

Introduction: Cognitive dysfunction is the most common problem of patients with Alzheimer Disease (AD). The pathological mechanism of cognitive impairment in AD may contribute to neuronal loss, synaptic dysfunction, and alteration in neurotransmitters receptors. Mitochondrial synapses dysfunction due to the accumulation of Amyloid Beta (Aβ) is one of the earliest pathological features of AD. The flavone apigenin has been reported to play some protective roles in AD through the anti-oxidative and anti-inflammatory properties. This study aimed at investigating the effects of apigenin on spatial working memory and neural protection byrestoring mitochondrial dysfunction and inhibition of caspase 9.

Methods: Intracerebroventricular (ICV) microinjection of Aβ 25-35 was used for AD modeling. Working memory was assessed 21 days later using the Y maze test. Neuronal loss was detected in the hilar area of the hippocampus using Nissl and Fluoro-jade B staining, whereas immunohistochemistry was used to illustrate cytochrome c positive cells and caspase 9.

Results: The results revealed that apigenin significantly ameliorated spatial working memory. It also significantly reduced the number of degenerative neurons in the hilus area. Apigenin almost completely blocked the release of cytochrome c and caspase 9 in hilus.

Conclusion: Apigenin may improve the spatial working memory deficits and neuronal degeneration through the amelioration of the mitochondrial dysfunction.

Study Type : In Vitro Study

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Sayer Ji
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