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Abstract Title:

Apamin from bee venom suppresses inflammation in a murine model of gouty arthritis.

Abstract Source:

J Ethnopharmacol. 2020 Apr 11 ;257:112860. Epub 2020 Apr 11. PMID: 32289477

Abstract Author(s):

Yun Mi Lee, Soo-Na Cho, Eunjung Son, Chang-Hwa Song, Dong-Seon Kim

Article Affiliation:

Yun Mi Lee

Abstract:

ETHNOPHARMACOLOGICAL RELEVANCE: Bee venom (BV) has been used for the treatment of inflammatory diseases, such as rheumatoid arthritis, and for the relief of pain in traditional oriental medicine.

AIM OF STUDY: The aim of this study was to determine the anti-inflammatory effect of BV on monosodium urate (MSU)-induced gouty arthritis in a mouse model.

MATERIALS AND METHODS: To develop a mouse model of acute gouty arthritis, 4 mg 50 μLof MSU crystal suspension was injected intradermally into the right paw. After MSU crystal injection, we evaluated inflammatory cytokine production in mice of the BV-treated (0.5 and 1 mg kgbody weight) and apamin (APM)-treated (0.5 and 1 mg kgbody weight) groups. The positive control group was administered a colchicine (1 mg kgbody weight) injection with MSU crystals.

RESULTS: BV and APM treatment suppressed inflammatory paw edema in MSU-administered mice. It also exerted anti-inflammatory effects in mice with gouty arthritis by inhibiting proinflammatory cytokine production and inflammasome formation. Interestingly, MSU crystal formation was decreased by BV and APM treatment.

CONCLUSIONS: These results suggest that the APM from BV might be useful for the treatment of gouty arthritis due to its anti-inflammatory activities.

Study Type : Animal Study

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Sayer Ji
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