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Abstract Title:

Antiviral Meroterpenoid Rhodatin and Sesquiterpenoids Rhodocoranes A-E from the Wrinkled Peach Mushroom, Rhodotus palmatus.

Abstract Source:

Org Lett. 2019 05 3 ;21(9):3286-3289. Epub 2019 Apr 22. PMID: 31008606

Abstract Author(s):

Birthe Sandargo, Maira Michehl, Dimas Praditya, Eike Steinmann, Marc Stadler, Frank Surup

Article Affiliation:

Birthe Sandargo

Abstract:

Rhodatin (1), a meroterpenoid featuring a unique pentacyclic scaffold with both spiro and spiroketal centers, and five unusual acorane-type sesquiterpenoids, named rhodocoranes A-E (2-6, respectively), are the first natural products isolated from the basidiomycete Rhodotus palmatus. Their structures were elucidated by two-dimensional NMR experiments and HRESIMS, while the absolute configuration of the substance family was determined by Mosher's method utilizing 2. Rhodatin strongly inhibited hepatitis C virus, whereas 4 displayed cytotoxicity and selective antifungal activity.

Study Type : In Vitro Study

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