Abstract Title:

Antioxidant, cholinesterase inhibition activities and essential oil analysis of Nelumbo nucifera seeds.

Abstract Source:

Nat Prod Res. 2016 Jun ;30(11):1335-8. Epub 2015 Jul 27. PMID: 26212099

Abstract Author(s):

Shahnaz Khan, Hidayatullah Khan, Farman Ali, Nayab Ali, Fahim Ullah Khan, Sami Ullah Khan

Article Affiliation:

Shahnaz Khan


Nelumbo nucifera seeds' essential oil (EO), crude extract and subsequent fractions were evaluated for their DPPH, ABTS and superoxide anion-free radical scavenging and cholinesterase inhibitory activities. The ethyl acetate fraction and EO showed outstanding antioxidant activities with IC50 values of 191, 450 μg/mL (DPPH), 123, 221 μg/mL (ABTS) and 69, 370 μg/mL (superoxide anion). The ethyl acetate fraction and EO also caused significant inhibition of acetylcholinesterase and butyrylcholinesterase with IC50 values of 70 ± 0.6, 64 ± 0.8 and 75 ± 0.3, 58 ± 0.2, in dose-dependent manner.The first ever gas chromatography-mass spectrometry analysis of the EO obtained from N. nucifera seeds resulted in identification of 19 constituents, mainly comprised of oxygenated sesquiterpenes responsible for their promising bioactivity. The crude and fractions revealed the presence of saponins,flavonoids, steroids, alkaloids, terpenoids and cardiac glycosides in phytochemical investigation.

Study Type : In Vitro Study

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