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Abstract Title:

Antioxidant and Anti-inflammatory Effect of ProbioticKU15149 Derived from Korean Homemade Diced-Radish Kimchi.

Abstract Source:

J Microbiol Biotechnol. 2020 Mar 24. Epub 2020 Mar 24. PMID: 32238771

Abstract Author(s):

Kyoung Jun Han, Ji-Eun Lee, Na-Kyoung Lee, Hyun-Dong Paik

Article Affiliation:

Kyoung Jun Han

Abstract:

KU15149 was demonstrated to have probiotic behavior and functions, including antioxidant and anti-inflammatory activity.KU15149 obtained from homemade diced-radish kimchi and has a high survival rate under artificial gastric acid (pH 2.5, 0.3% pepsin) and bile salt (0.3% oxgall) conditions. However,KU15149 did not produceβ-glucuronidase, which is known to be a carcinogenic enzyme with resistance to several antibiotics, such as gentamycin, kanamycin, streptomycin, tetracycline, and ciprofloxacin.KU15149 strongly adhered to HT-29 cells and had a high antioxidant activity in terms of 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical-scavenging andβ-carotene bleaching assays.KU15149 also exhibited a pronounced inhibition of nitric oxide (NO) production, along with expression of nitric oxide synthase () and cyclooxygenase -2 () as well as pro-inflammatory cytokines, such as,, and, when RAW 264.7 cells were stimulated with LPS. Therefore,KU15149 was demonstrated to have pharmaceutical functionality as a potential probiotic.

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