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Article Publish Status: FREE
Abstract Title:

Antioxidant and alpha-amylase inhibitory potentials ofhusk.

Abstract Source:

Food Sci Nutr. 2018 Sep ;6(6):1676-1683. Epub 2018 Jul 20. PMID: 30258612

Abstract Author(s):

Hamdalat Folake Muritala, Jubril Olayinka Akolade, Sarah Abimbola Akande, Azeemat Titilola Abdulazeez, Raliat Abimbola Aladodo, Abdulkabir Bolakale Bello

Article Affiliation:

Hamdalat Folake Muritala

Abstract:

Concoctions containing extract fromhusk fiber are used in Nigeria by traditional medicine practitioners for management of diabetes and its associated complications. Preliminary antidiabetic study was designed to validate the folkloric usage of the plant extract. Dried coconut husk fiber was pulverized and extracted with methanol, followed by partitioning of the methanolic extract in ethyl acetate. Phenolic content, radical scavenging activity and antioxidant capacity as well as inhibitory effects ofmethanolic (CN-M) extract and its ethyl acetate (CN-E) fraction on pancreaticα-amylase and lipid peroxidation were determined. Total phenolic content and antioxidant capacity of CN-E fraction were significantly higher than that of CN-M extract, whereas there was no significant difference in their ability to scavenge free radicals. The CN-E fraction also exhibited higher invitro and in vivo inhibitory effects on α-amylase activity and lipid peroxidation; reducing blood glucose level within 5 days following intraperitoneal administration of theextract to alloxan-induced hyperglycemic rats. The phenolic-rich extracts from coconut husk can be further explored as nutraceutical supplement in food formulation for diabetic patients.

Study Type : Animal Study, In Vitro Study

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