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Article Publish Status: FREE
Abstract Title:

Antimicrobial Activity of Silver-Treated Bacteria against other Multi-Drug Resistant Pathogens in Their Environment.

Abstract Source:

Antibiotics (Basel). 2020 Apr 15 ;9(4). Epub 2020 Apr 15. PMID: 32326384

Abstract Author(s):

Doaa Safwat Mohamed, Rehab Mahmoud Abd El-Baky, Tim Sandle, Sahar A Mandour, Eman Farouk Ahmed

Article Affiliation:

Doaa Safwat Mohamed

Abstract:

Silver is a potent antimicrobial agent against a variety of microorganisms and once the element has entered the bacterial cell, it accumulates as silver nanoparticles with large surface area causing cell death. At the same time, the bacterial cell becomes a reservoir for silver. This study aims to test the microcidal effect of silver-killedO104: H4 and its supernatant against fresh viable cells of the same bacterium and some other species, includingO157: H7, Multidrug Resistant (MDR)and Methicillin Resistant(MRSA). Silver-killed bacteria were examined by Transmission Electron Microscopy (TEM). Agar well diffusion assay was used to test the antimicrobial efficacy and durability of both pellet suspension and supernatant of silver-killedO104:H4 against other bacteria. Both silver-killed bacteria and supernatant showed prolonged antimicrobial activity against the tested strains that extended to 40 days. The presence of adsorbed silver nanoparticles on the bacterial cell and inside the cells was verified by TEM. Silver-killed bacteria serve as an efficient sustained release reservoir for exporting the lethal silver cations. This promotes its use as a powerful disinfectant for polluted water and as an effective antibacterial which can be included in wound and burn dressings to overcome the problem of wound contamination.

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