Article Publish Status: FREE
Abstract Title:

Antihyperglycemic and Antiobesity Effects of JAL2 on db/db Mice.

Abstract Source:

Evid Based Complement Alternat Med. 2016 ;2016:6828514. Epub 2016 Mar 16. PMID: 27069493

Abstract Author(s):

In-Seung Lee, Ki-Suk Kim, Kang-Hoon Kim, Jiyoung Park, Hyeon-Soo Jeong, Yumi Kim, Yun-Cheol Na, Won Seok Chung, Kwang-Seok Ahn, Seok-Geun Lee, Jae Young Um, Jun Hee Lee, Hyeung-Jin Jang

Article Affiliation:

In-Seung Lee


Lonicera japonica Thunb. (LJT) and Rehmannia glutinosa Libosch. (RGL) have been used traditionally as a herbal medicine in Korean medicine. Using LC/Q-TOF was performed to profile the two herbal medicines and the mixture of LJR and RGL (JAL2, ratio 1 : 1). We performed oral glucose tolerance test (OGTT) and plasma GLP-1 and insulin secretion by multiplex assays to investigate antidiabetic effects of LJT, RGL, and JAL2 in db/db mice, the mice model of type 2 diabetes mellitus (T2DM). Also, the antiobesity-related factors such as plasma peptide YY (PYY), triglyceride, total cholesterol, HDL, LDL, and weight of liver, epididymal, and retroperitoneal fat tissue were investigated. Through the multiplex assay, it was found that JAL2 treatment more efficiently attenuated high levels of blood glucose by stimulating GLP-1 secretion and reducedLDL concentration and weight of liver and retroperitoneal fat tissue compared to LJT or RGL treated separately. These results suggest that the JAL2 has antidiabetes and antiobesity effects in T2DM mice model.

Study Type : Animal Study

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